Systemic Contact Dermatitis

Leyla BAYKAL SELÇUKa , Ali Osman METİNTAŞa

aKaradeniz Technical University Faculty of Medicine, Department of Dermatology, Trabzon, Türkiye

Baykal Selçuk L, Metintaş AO. Systemic contact dermatitis. In: Günaştı Topal S, ed. Contact Dermatitis. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.32-8.

ABSTRACT

Systemic contact dermatitis is a clinical condition characterized by a delayed-type (type 4) hypersensitivity reaction that develops in individuals previously sensitized to an allergen through the skin, following systemic re-exposure. Systemic contact dermatitis consists of subgroups with similar pathophysiologies. The precise mechanism underlying systemic contact dermatitis reactions has not yet been clearly defined. The disease can be triggered by a wide variety of plants, foods, metals, and medications. Patch testing with suspected agents is recommended for patients who achieve remission after necessary treatment. The primary approach to systemic contact dermatitis treatment is identifying and eliminating the causative allergen. After discontinuing contact with the culprit allergen, skin findings typically regress with desquamation within a few weeks.

Keywords: Contact dermatitis, systemic; patch tests; metal; dermatitis, allergic contact

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