FROM NEUROSCIENCE LABORATORY TO NEUROLOGY CLINIC

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THE GLYMPHATIC SYSTEM IN NEURODEGENERATION: ALZHEIMER’S DISEASE

Fadime Çadırcı Tungaç

İstanbul Medipol University, Vocational School, Program of Electroneurophysiology, İstanbul, Türkiye

Çadırcı Tungaç F. The Glymphatic System In Neurodegeneration: Alzheimer’s Disease. In: Hanoğlu L, editor. From Neuroscience Laboratory to Neurology Clinic. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.4148.

ABSTRACT

The accumulation of amyloid plaques and neurofibrillary tangles in the brain parenchyma is one of the factors that disrupt the functioning of cognitive processes. Astrocytes play a significant role in eliminating this accumulation and assisting in the proper collection of waste thus, are highly significant for longevity and the maintenance of cognitive capacities. Prominent research indicates that the glymphatic system eliminates over half of the plaque deposition and plays a major role in maintaining the functionality of the central nervous system (CNS). Studies of the underlying mechanisms in neurodegenerative diseases like Alzheimer’s disease (AD) are yet unknown. However, glymphatic clearance as a means of addressing AD and other novel approaches in this field offer an original point of view that clarifies this process. Novel studies employing various methodologies and demonstrating increased glymphatic system activity during sleep, particularly during sleepwake cycles, holds significant value in comprehending the fundamental mechanisms of neurodegenerative diseases and acquiring novel scientific understanding in which are critical for newer therapeutic interventions.

Keywords: Alzheimer’s disease; Astrocyte; Glymphatic system; Neurodegenerative diseases; Sleepwake

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