The Importance of Mitochondrial DNA in Cancer

tibbibiyolojiozel-2-2-24kapak

Sezen GÜNTEKİN ERGÜNa
aHacettepe University Faculty of Medicine, Department of Medical Biology, Ankara, Türkiye

Güntekin Ergün S. The importance of mitochondrial DNA in cancer. In: Yar Sağlam AS, ed. Innovative Approaches in Cancer Diagnosis and Treatment. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.13-7.

Makale Dili: EN

ABSTRACT
Mitochondria play important roles in mechanisms such as metabolism, oxidative stress, apoptosis and cell survival. Many studies have been conducted on the role of mitochondria in the formation and progression of cancer. However, there are still unknown aspects of this relationship. In this study, the relationship between mitochondria and cancer is presented from a general perspective.

Keywords: Cancer; DNA, mitochondrial

Referanslar

  1. Ernster L, Schatz G. Mitochondria: a historical review. Journal of Cell Biology. 1981;91(3):227-55. [Crossref]  [PubMed]  [PMC]
  2. Verschoor ML, Ungard R, Harbottle A, Jakupciak JP, Parr RL, Singh G. Mitochondria and cancer: past, present, and future. Biomed Res Int. 2013;2013:612369. [Crossref]  [PubMed]  [PMC]
  3. Siekevitz P. Powerhouse of the Cell. Scientific American. 1957;197(1):131-44. [Crossref]
  4. Nass MM, Nass S. Intramitochondrial fibers with DNA characteristics. I. Fixation and electron staining reactions. J Cell Biol. 1963;19(3):593-611. [Crossref]  [PubMed]  [PMC]
  5. Chial H, Craig J. mtDNA and mitochondrial diseases. Nature Education. 2018;1(1):217.
  6. Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, et al. Sequence and organization of the human mitochondrial genome. Nature. 1981;290(5806):457-65. [Crossref]  [PubMed]
  7. Garcia I, Jones E, Ramos M, Innis-Whitehouse W, Gilkerson R. The little big genome: the organization of mitochondrial DNA. Front Biosci (Landmark Ed). 2017;22(4):710-21. [Crossref]  [PubMed]  [PMC]
  8. Cavalier-Smith T. Origin of mitochondria by intracellular enslavement of a photosynthetic purple bacterium. Proc Biol Sci. 2006;273(1596):1943-52. [Crossref]  [PubMed]  [PMC]
  9. Lin YH, Lim SN, Chen CY, Chi HC, Yeh CT, Lin WR. Functional Role of Mitochondrial DNA in Cancer Progression. Int J Mol Sci. 2022;23(3):1659. [Crossref]  [PubMed]  [PMC]
  10. Liu C, Jin Y, Fan Z. The mechanism of Warburg effect-induced chemoresistance in cancer. Front. Oncol. 2021;11:698023. [Crossref]  [PubMed]  [PMC]
  11. Habbane M, Montoya J, Rhouda T, Sbaoui Y, Radallah D, Emperador S. Human Mitochondrial DNA: Particularities and Diseases. Biomedicines. 2021;9(10):1364. [Crossref]  [PubMed]  [PMC]
  12. Li H, Slone J, Fei L, Huang T. Mitochondrial DNA Variants and Common Diseases: A Mathematical Model for the Diversity of Age-Related mtDNA Mutations. Cells. 2019;8(6):608. [Crossref]  [PubMed]  [PMC]
  13. Rahman S, Copeland WC. POLG-related disorders and their neurological manifestations. Nat Rev Neurol. 2019;15(1):40-52. [Crossref]  [PubMed]  [PMC]
  14. Hernansanz-Agustín P, Enríquez JA. Generation of Reactive Oxygen Species by Mitochondria. Antioxidants (Basel). 2021;10(3):415. [Crossref]  [PubMed]  [PMC]
  15. Abbaszadeh Z, Çeşmeli S, Biray Avcı Ç. Crucial players in glycolysis: Cancer progress. Gene. 2020;726:144158. [Crossref]  [PubMed]
  16. Melkonian EA, Schury MP. Biochemistry, Anaerobic Glycolysis. [Updated 2023 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available from: [Link]
  17. Sabharwal SS, Schumacker PT. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? Nat Rev Cancer. 2014;14(11):709-21. [Crossref]  [PubMed]  [PMC]
  18. Kim E-K, Jang M, Song M-J, Kim D, Kim Y, Jang HH. Redox-Mediated Mechanism of Chemoresistance in Cancer Cells. Antioxidants. 2019; 8(10):471. [Crossref]  [PubMed]  [PMC]
  19. Ingman M, Kaessmann H, Pääbo S, Gyllensten U. Mitochondrial genome variation and the origin of modern humans. Nature. 2000;408(6813):708-13. [Crossref]  [PubMed]
  20. Okon IS, Zou MH. Mitochondrial ROS and cancer drug resistance: Implications for therapy. Pharmacol. Res. 2015;100:170-4. [Crossref]  [PubMed]  [PMC]
  21. Mukherjee S, Bhatti GK, Chhabra R, Reddy PH, Bhatti JS. Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer. Biomedicine & Pharmacotherapy. 2023;160:114398. [Crossref]  [PubMed]
  22. Larsen NB, Rasmussen M, Rasmussen LJ. Nuclear and mitochondrial DNA repair: similar pathways? Mitochondrion. 2005;5:89-108. [Crossref]  [PubMed]
  23. Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, et al. PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 2013;23(3):287-301. [Crossref]  [PubMed]  [PMC]
  24. Shidara Y, Yamagata K, Kanamori T, Nakano K, Kwong JQ, Manfredi G, et al. Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis. Cancer Res. 2005;65(5):1655-63. [Crossref]  [PubMed]
  25. Rosolen D, Nunes-Souza E, Marchi R, Tofolo MV, Antunes VC, Berti FCB, et al. MiRNAs Action and Impact on Mitochondria Function, Metabolic Reprogramming and Chemoresistance of Cancer Cells: A Systematic Review. Biomedicines. 2023;11(3):693. [Crossref]  [PubMed]  [PMC]
  26. Vandenabeele P, Bultynck G, Savvides SN. Pore-forming proteins as drivers of membrane permeabilization in cell death pathways. Nat Rev Mol Cell Biol. 2023;24:312-33. [Crossref]  [PubMed]
  27. Aranda-Rivera AK, Cruz-Gregorio A, Arancibia-Hernández YL, Hernández-Cruz EY, Pedraza-Chaverri J. RONS and Oxidative Stress: An Overview of Basic Concepts. Oxygen. 2022;2(4):437-78. [Crossref]
  28. Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metabolism. 2006;3(3):177-85. [Crossref]  [PubMed]
  29. Grasso D, Zampieri LX, Capelôa T, Van de Velde JA, Sonveaux P. Mitochondria in cancer. Cell Stress. 2020;4(6):114-46. [Crossref]  [PubMed]  [PMC]
  30. Chen K, Lu P, Beeraka NM, Sukocheva OA, Madhunapantula SV, Liu J, et al. Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers. Semin Cancer Biol. 2022;83:556-69. [Crossref]  [PubMed]
  31. Kumar S, Ashraf R, Aparna CK. Mitochondrial dynamics regulators: implications for therapeutic intervention in cancer. Cell Biol Toxicol. 2022;38:377-406. [Crossref]  [PubMed]