PULMONARY PATHOLOGIES AND MANAGEMENT STRATEGIES IN PRIMARY IMMUNODEFICIENCIES

pulmonary_pathologies_kapak

THE ROLE OF LABORATORY TESTS, IMAGING MODALITIES, AND LUNG BIOPSY IN DIAGNOSING PULMONARY COMPLICATIONS

Öykü Ünsal1
Mustafa Güleç2

1University of Health Sciences, Gülhane Training and Research Hospital, Department Immunology and Allergic Disease, Ankara, Türkiye
2Güven Hospital, Department of Immunology and Allergic Diseases, Ankara, Türkiye

Ünsal Ö, Güleç M. The Role of Laboratory Tests, Imaging Modalities, and Lung Biopsy in Diagnosing Pulmonary Complications. In: Arslan Ş editor. Pulmonary Pathologies and Management Strategies in Primary Immunodeficiencies. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.105-116.

ABSTRACT

Despite optimal immunoglobulin replacement therapy, respiratory complications can develop in primary immunodeficiencies due to underlying clinical conditions, infections, and inflammation. Therefore, these patients should be closely monitored for potential pulmonary complications. Pulmonary complications include infectious complications (acute and chronic infections, bronchiectasis), non-infectious immune-mediated complications (intersititial lung diseases, autoimmunity-related lung diseases) and neoplastic diseases (mediastinal/hilar lymphadenopathy, lymphoma and malignancies). Given the association of pulmonary complications with significant morbidity and mortality, timely diagnosis and appropriate treatment can halt or at least slow the progression of these complications. Hence, methods and screening procedures used in the diagnosis of pulmonary complications play an critical role in the management and follow-up of these patients. In this section, the role of laboratory tests, imaging methods and lung biopsy in the diagnosis of pulmonary complications in primary immunodeficiencies is discussed.

Keywords: Primary immunodeficiency diseases; Pulmonary complications; Laboratory tests; Pulmonary function test; Imaging modalities; Lung biopsy

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