MICROBIOTA

microbiotakapak

THE ROLE OF MICROBIOTA IN INFECTIONS DEVELOPING AFTER ORTHOPEDIC IMPLANTS AND SURGICAL INTERVENTIONS

Yunus Emre Bulum1
Ömer Faruk Yılmaz2

1İstanbul Göztepe Prof. Dr. Suleyman Yalçın City Hospital, Department of Orthopedics and Traumatology, İstanbul, Türkiye
2Tekirdağ Çorlu State Hospital, Department of Orthopedics and Traumatology, Tekirdağ, Türkiye

Bulum YE, Yılmaz ÖF. The Role of Microbiota in Infections Developing After Orthopedic Implants and Surgical Interventions. Melek İM, Aydoğan S, eds. Microbiota. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.163-170.

ABSTRACT

The gut microbiota, a collection of microorganisms in the digestive tract, plays a crucial role in human health, particularly influencing the immune system and musculoskeletal communication through the metabolites it produces. Dysbiosis, a disruption of the microbiome balance, is linked to various conditions, including inflammatory bowel disease (IBD), obesity, and diabetes, which increase the risk of orthopedic diseases. Recent research suggests a strong connection between gut health and orthopedic conditions such as osteoarthritis (OA), aseptic loosening, and periprosthetic joint infections (PJI). Dysbiosis, through increased intestinal permeability and systemic inflammation, may accelerate the development of OA and compromise implant integration. Studies have shown that certain gut microbes are associated with the severity of cartilage damage and joint infections. Given the influence of gut microbiota on bone health, probiotics are emerging as a potential therapeutic option for patients with hip and knee implants. However, questions remain regarding the optimal doses, treatment durations, and long-term effects of probiotics. Additionally, the use of fecal microbiota transplantation (FMT) shows promise for improving gut health in high-risk patients, though further research is necessary. Personalized probiotic treatments, tailored to the specific needs of individuals, may become a valuable tool in reducing aseptic loosening and PJI in orthopedic patients.

Keywords: Fecal microbiota transplantation; Surgical wound infection; Osteoarthritis; Osteoporosis; Periprosthetic fractures; Prosthesis failure; Microbiota; Probiotics

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