Trauma and Inflammation

biyomedikalozel5-1-24kapak

A. Murat ÖZTÜRKa , Arman VAHABİa
aEge University Faculty of Medicine, Department of Orthopaedics and Traumatology, İzmir, Türkiye

Öztürk AM, Vahabi A. Trauma and inflammation. In: Koçdor H, Pabuççuoğlu A, Zihnioğlu F, eds. Inflammation and in vitro Diagnostics. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.123-8.

Article Language: EN

ABSTRACT
Management of severely injured patients is a complicated process with so many questions that need to be answered. Understanding the immune mechanisms and complex physiological responses to trauma is at utmost importance to provide appropriate and up-to-date care. The organism’s immune response to trauma is a balanced interactions of inflammatory and anti-inflammatory mediators which purpose is to eliminate the insult faced by the organism and returning it to its pre-injury state. Initial inflammatory response after a trauma described on two main molecular patterns: Damage associated molecular pattern (DAMP) and pathogen associated molecular pattern (PAMP). These patterns act as ”signal 0”. DAMPs are well described inflammatory trigger mediators. In severely traumatized patients, treatment protocols should be made with considerations on described immune responses and their clinical effects. Staged approach with ”damage control” philosophy should be treatment of choice according to current published literature.

Keywords: Inflammation; immune response; trauma

Referanslar

  1. Lord JM, Midwinter MJ, Chen YF, et al. The systemic immune response to trauma: an overview of pathophysiology and treatment. Lancet. 2014;384(9952):1455. [Crossref]  [PubMed]
  2. Sauaia A, Moore FA, Moore EE. Postinjury Inflammation and Organ Dysfunction. Crit Care Clin. 2017;33(1):167. [Crossref]  [PubMed]  [PMC]
  3. Tsukamoto T. Local Inflammatory Changes Induced by Fractures and Soft Tissue Injuries. The Poly-Traumatized Patient with Fractures. Published online 2011;19-31. [Crossref]
  4. Tosounidis T, Giannoudis P v. Pathophysiology of Polytrauma. The Poly-Traumatized Patient with Fractures. Published online 2011;33-41. [Crossref]
  5. Huber-Lang M, Lambris JD, Ward PA. Innate immune responses to trauma. Nat Immunol. 2018;19(4):327-41. [Crossref]  [PubMed]  [PMC]
  6. Relja B, Mörs K, Marzi I. Danger signals in trauma. European Journal of Trauma and Emergency Surgery. 2018;44(3):301. [Crossref]  [PubMed]  [PMC]
  7. Moriyama K, Nishida O. Targeting Cytokines, Pathogen-Associated Molecular Patterns, and Damage-Associated Molecular Patterns in Sepsis via Blood Purification. Int J Mol Sci. 2021;22(16). [Crossref]  [PubMed]  [PMC]
  8. Roh JS, Sohn DH. Damage-Associated Molecular Patterns in Inflammatory Diseases. Immune Netw. 2018;18(4). [Crossref]  [PubMed]  [PMC]
  9. Tang D, Kang R, Coyne CB, Zeh HJ, Lotze MT. PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev. 2012;249(1):158. [Crossref]  [PubMed]  [PMC]
  10. Pape HC, Moore EE, McKinley T, Sauaia A. Pathophysiology in patients with polytrauma. Injury. 2022;53(7):2400-12. [Crossref]  [PubMed]
  11. Lenz A, Franklin GA, Cheadle WG. Systemic inflammation after trauma. Injury. 2007;38(12):1336-45. [Crossref]  [PubMed]
  12. Nauth A, Hildebrand F, Vallier H, et al. Polytrauma: update on basic science and clinical evidence. OTA International. 2021;4(1):e116. [Crossref]  [PubMed]  [PMC]
  13. Vallier HA, Moore TA, Como JJ, et al. Complications are reduced with a protocol to standardize timing of fixation based on response to resuscitation. J Orthop Surg Res. 2015;10(1). [Crossref]  [PubMed]  [PMC]
  14. Vallier HA, Dolenc AJ, Moore TA. Early Appropriate Care: A Protocol to Standardize Resuscitation Assessment and to Expedite Fracture Care Reduces Hospital Stay and Enhances Revenue. J Orthop Trauma. 2016;30(6):306-11. [Crossref]  [PubMed]