TRAVMA VE ALKOL MADDE KULLANIM BOZUKLUKLARI
Cansu Çoban
Ankara Etlik Şehir Hastanesi, Psikiyatri Kliniği, Ankara, Türkiye
Çoban C. Travma ve Alkol Madde Kullanım Bozuklukları. Doğan Bulut S, editör. Özel Gruplarda Alkol ve Madde Kullanım Bozuklukları ve Tedavisi. 1. Baskı. Ankara: Türkiye Klinikleri; 2025. p.115-127.
ÖZET
Alkol-madde kullanım bozukluğu (AMKB) iş, sağlık ve sosyal yaşamda olumsuz sonuçları olmasına rağmen alkol-madde kullanımını sürdürme ile karakterize kronik ve tekrarlayıcı bir hastalıktır. Sıklıkla diğer ruhsal bozukluklarla bir arada görülür. Travma ile ilişkili bozukluklar AMKB’ye sıklıkla eşlik eder. Travma sonrası stres bozukluğu (TSSB) korkutucu bir şekilde ölüm ve ağır yaralanmayla karşılaşma veya cinsel saldırıya uğrama sonrasında başlayan yeniden yaşantılama, kaçınma, biliş ve duyguların olumsuz yönde etkilenmesi ve aşırı uyarılmışlık semptomları ile kendini gösteren bir sendromdur. TSSB’si olan birçok kişi belirtileri yatıştırmak için alkol veya madde kullanabilmektedir. TSSB’nin AMKB riskini artırdığı bilinmektedir. Bununla birlikte madde kullanım bozukluğu olan bireylerin de aşırı doz uygulama, arkadaşın ölümüne tanık olma, şiddete maruz kalma, cinsel saldırıya uğrama gibi travma veya stresli bir yaşam olayına maruz kalma riski artmıştır. Ayrıca AMKB olan bireylerde yoksunluk semptomları nedeniyle aşırı uyarılmanın eşlik etmesi, duygusal işlemlemenin olumsuz etkilenmesi gibi nedenlerle TSSB duyarlılığı da artmıştır. TSSB’nin AMKB riskini artırdığı gibi AMKB’nin de TSSB risk ve sıklığını artırdığı gösterilmiştir. İstismar, ihmal gibi olumsuz çocukluk çağı olayları eş tanılı AMKB ve TSSB için ortak risk faktörü olarak tanımlanmıştır. Ergenlik veya yetişkinlikte maruziyete kıyasla çocukluk çağında travma maruziyetinin olması TSSB ve AMKB’nin seyrinin daha olumsuz olmasına neden olmaktadır.
TSSB veya AMKB birbirinden bağımsız olarak ortaya çıktığında diğer ruhsal hastalık riskinin artması, bilişsel bozulma, işlevsellikte bozulma ile ilişkili olduğu bilinmektedir. TSSB ve AMKB eş tanılarının olması TSSB ve AMKB semptom şiddetinin, diğer psikiyatrik ek tanı riskinin artmasına, gidişin daha olumsuz seyretmesine ve yaşam kalitesinin daha düşük olmasına neden olmaktadır. Kişinin yaşam kalitesi ve işlevselliğini artırmak için eş tanılı TSSB ve AMKB’nin tedavisi büyük önem arz etmekte, tedavi ile ilgili birtakım güçlükleri de beraberinde getirmektedir. TSSB veya AMKB tedavisinde etkinliği gösterilmiş ve yaygın olarak kullanılan tedavi yaklaşımları mevcuttur. Tedavinin başından itibaren her iki bozukluğun tedavisi beraber ele alınmalıdır. Ancak eş tanılı AMKB ve TSSB için güncel bir tedavi kılavuzu bulunmamaktadır. Eş tanılı TSSB ve AMKB’si olan bireylerde farmakolojik tedavileri inceleyen az sayıda mevcut çalışmaların çoğu serotonerjik, noradrenerjik, opioiderjik, GABAerjik ve glutamaterjik sistemlere odaklanmıştır. TSSB ve AMKB için ayrı ayrı etkili psikoterapi uygulamaları pratikte uygulanmakla birlikte eş tanılı durumların tedavisinde daha kapsamlı yaklaşımlara ihtiyaç vardır. Bu bağlamda entegre-bütünleşik psikoterapilerin geliştirilme ihtiyacı gündeme gelmiştir. Güven arayışı terapisi ve bütünleşik maruz kalma terapileri sıklıkla uygulanan ve etkinliği gösterilmiş bilişsel davranışçı temelli bütünleşik terapilerdir.
Anahtar Kelimeler: Travma; Travma sonrası stres bozukluğu; Alkol kullanım bozukluğu; Madde kullanım bozukluğu
Kaynak Göster
Referanslar
- Anthenelli RM, Brady KT, Grandison L, Roach D. Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder. Alcohol research: current reviews. 2018;39(2):111-2.
- Smith ND, Cottler LB. The epidemiology of post-traumatic stress disorder and alcohol use disorder. Alcohol research: current reviews. 2018;39(2):113.
- American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Association. [Crossref]
- Amstadter AB, Lönn S, Sundquist J, Sundquist K, Kendler KS. Post-traumatic stress disorder and drug use disorder: examination of aetiological models in a Swedish population-based cohort. European Journal of Psychotraumatology. 2023;14(2):2258312. [Crossref] [PubMed] [PMC]
- Dell'Aquila A, Berle D. Predictors of alcohol and substance use among people with post-traumatic stress disorder (PTSD): findings from the NESARC-III study. Social psychiatry and psychiatric epidemiology. 2023;58(10):1509-22. [Crossref] [PubMed] [PMC]
- Nguyen J, Whiteside LK, Bulger EM, Veach L, Moloney K, Russo J, et al. Post-traumatic stress disorder (PTSD) symptoms and alcohol and drug use comorbidity at 25 US level I trauma centers. Trauma Surgery & Acute Care Open. 2022;7(1):e000913. [Crossref] [PubMed] [PMC]
- Pietrzak RH, Goldstein RB, Southwick SM, Grant BF. Prevalence and Axis I comorbidity of full and partial posttraumatic stress disorder in the United States: Results from Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. Journal of anxiety disorders. 2011;25(3):456-65. [Crossref] [PubMed] [PMC]
- Mills KL, Teesson M, Ross J, Peters L. Trauma, PTSD, and substance use disorders: findings from the Australian National Survey of Mental Health and Well-Being. American journal of psychiatry. 2006;163(4):652-8. [Crossref] [PubMed]
- Straus E, Haller M, Lyons RC, Norman SB. Functional and psychiatric correlates of comorbid post-traumatic stress disorder and alcohol use disorder. Alcohol Research: Current Reviews. 2018;39(2):121.
- Hien DA, Jiang H, Campbell AN, Hu M-C, Miele GM, Cohen LR, et al. Do treatment improvements in PTSD severity affect substance use outcomes? A secondary analysis from a randomized clinical trial in NIDA's Clinical Trials Network. American Journal of Psychiatry. 2010;167(1):95-101. [Crossref] [PubMed] [PMC]
- De Bellis MD. Developmental traumatology: a contributory mechanism for alcohol and substance use disorders. Psychoneuroendocrinology. 2002;27(1-2):155-70. [Crossref] [PubMed]
- Müller M, Vandeleur C, Rodgers S, Rössler W, Castelao E, Preisig M, Ajdacic-Gross V. Childhood adversities as specific contributors to the co-occurrence of posttraumatic stress and alcohol use disorders. Psychiatry research. 2015;228(3):251-6. [Crossref] [PubMed]
- Waldrop AE, Santa Ana EJ, Saladin ME, McRae AL, Brady KT. Differences in early onset alcohol use and heavy drinking among persons with childhood and adulthood trauma. American Journal on Addictions. 2007;16(6):439-42. [Crossref] [PubMed]
- Riggs DS, Rukstalis M, Volpicelli JR, Kalmanson D, Foa EB. Demographic and social adjustment characteristics of patients with comorbid posttraumatic stress disorder and alcohol dependence: Potential pitfalls to PTSD treatment. Addictive Behaviors. 2003;28(9):1717-30. [Crossref] [PubMed]
- Dutton CE, Adams T, Bujarski S, Badour CL, Feldner MT. Posttraumatic stress disorder and alcohol dependence: Individual and combined associations with social network problems. Journal of anxiety disorders. 2014;28(1):67-74. [Crossref] [PubMed]
- Drapkin ML, Yusko D, Yasinski C, Oslin D, Hembree EA, Foa EB. Baseline functioning among individuals with posttraumatic stress disorder and alcohol dependence. Journal of Substance Abuse Treatment. 2011;41(2):186-92. [Crossref] [PubMed] [PMC]
- Bonn-Miller MO, Vujanovic AA, Drescher KD. Cannabis use among military veterans after residential treatment for posttraumatic stress disorder. Psychol Addict Behav. 2011;25(3):485-91. [Crossref] [PubMed]
- de Silva VA, Jayasekera N, Hanwella R. Cannabis use among Navy personnel in Sri Lanka: a cross sectional study. BMC Res Notes. 2016;9:174. [Crossref] [PubMed] [PMC]
- Kulak JA, Homish DL, Kozlowski LT, Homish GG. Cannabis Use and Perceptions Among Current and Former Military Service Members. Cannabis. 2023;6(2):104-112. [Crossref] [PubMed] [PMC]
- Dunlop SA, Archer MA, Quinlivan JA, Beazley LD, Newnham JP. Repeated prenatal corticosteroids delay myelination in the ovine central nervous system. Journal of Maternal-Fetal Medicine. 1997;6(6):309-13. [Crossref]
- Katona I, Rancz EA, Acsády L, Ledent C, Mackie K, Hájos N, et al. Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission. Journal of Neuroscience. 2001;21(23):9506-18. [Crossref] [PubMed] [PMC]
- Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng M-Q, Gujarro-Anton A, et al. Elevated brain cannabinoid CB1 receptor availability in post-traum2657.
- Shorter D, Hsieh J, Kosten TR. Pharmacologic management of comorbid post-traumatic stress disorder and addictions. The American journal on addictions. 2015;24(8):705-12. [Crossref] [PubMed]
- Roberts NP, Lotzin A, Schäfer I. Psychological treatment of PTSD with comorbid substance use disorder (SUD): expert recommendations of the European Society for Traumatic Stress Studies (ESTSS). European Journal of Psychotraumatology. 2023;14(2):2265773. [Crossref] [PubMed] [PMC]
- Verplaetse TL, McKee SA, Petrakis IL. Pharmacotherapy for Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder: Targeting the Opioidergic, Noradrenergic, Serotonergic, and GABAergic/Glutamatergic Systems. Alcohol Res. 2018;39(2):193-205. [PubMed] [PMC]
- Tregub T, Lytvynenko M, Kukushkin V, Chebotarova S, Oliynyk N, Gulbs O, et al. Pharmacology of Post-traumatıc Stress Dısorder. Georgian Med News. 2023 Sep;(342):122-124. [PubMed]
- Brady KT, Sonne SC, Roberts JM. Sertraline treatment of comorbid posttraumatic stress disorder and alcohol dependence. J Clin Psychiatry. 1995 Nov;56(11):502-5. [PubMed]
- Brady KT, Sonne S, Anton RF, Randall CL, Back SE, Simpson K. Sertraline in the treatment of co-occurring alcohol dependence and posttraumatic stress disorder. Alcoholism: Clinical and Experimental Research. 2005;29(3):395-401. [Crossref] [PubMed]
- Back SE, Brady KT, Sonne SC, Verduin ML. Symptom improvement in co-occurring PTSD and alcohol dependence. The Journal of nervous and mental disease. 2006;194(9):690-6. [Crossref] [PubMed]
- Fluyau D, Mitra P, Jain A, Kailasam VK, Pierre CG. Selective serotonin reuptake inhibitors in the treatment of depression, anxiety, and post-traumatic stress disorder in substance use disorders: a Bayesian meta-analysis. European Journal of Clinical Pharmacology. 2022;78(6):931-42. [Crossref] [PubMed]
- Greenbaum MA, Neylan TC, Rosen CS. Symptom presentation and prescription of sleep medications for veterans with posttraumatic stress disorder. The Journal of Nervous and Mental Disease. 2017 Feb 1;205(2):112-8. [Crossref] [PubMed]
- Simon PYR, Rousseau P-F. Treatment of post-traumatic stress disorders with the alpha-1 adrenergic antagonist prazosin: A review of outcome studies. The Canadian Journal of Psychiatry. 2017;62(3):186-98. [Crossref] [PubMed] [PMC]
- Simpson TL, Saxon AJ, Meredith CW, Malte CA, McBride B, Ferguson LC, et al. A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. Alcoholism: Clinical and Experimental Research. 2009;33(2):255-63. [Crossref] [PubMed]
- Simpson TL, Malte CA, Dietel B, Tell D, Pocock I, Lyons R, et al. A pilot trial of prazosin, an alpha-1 adrenergic antagonist, for comorbid alcohol dependence and posttraumatic stress disorder. Alcoholism: Clinical and Experimental Research. 2015;39(5):808-17. [Crossref] [PubMed] [PMC]
- Petrakis IL, Desai N, Gueorguieva R, Arias A, O'Brien E, Jane JS, et al. Prazosin for veterans with posttraumatic stress disorder and comorbid alcohol dependence: a clinical trial. Alcoholism: Clinical and Experimental Research. 2016;40(1):178-86. [Crossref] [PubMed]
- Richards A, Inslicht S, Ruoff LM, Metzler TJ, Goldstein LA, Chapman CM, et al. An Open-Label Study of Doxazosin Extended-Release for PTSD: Findings and Recommendations for Future Research on Doxazosin. Focus (Am Psychiatr Publ). 2018;16(1):67-73. [Crossref] [PubMed] [PMC]
- Back SE, Flanagan JC, Mintz J, Brady KT, Jones J, Jarnecke AM, et al. A double-blind randomized controlled trial of doxazosin for co-occurring PTSD and alcohol use disorder in veterans. The Journal of Clinical Psychiatry. 2023;84(2):46081. [Crossref] [PubMed]
- Back SE, Flanagan JC, Jones JL, Augur I, Peterson AL, Young-McCaughan S, Shirley DW, Henschel A, Joseph JE, Litz BT, Hancock AK, Roache JD, Mintz J, Wachen JS, Keane TM, Brady KT; Consortium to Alleviate PTSD. Doxazosin for the treatment of co-occurring PTSD and alcohol use disorder: Design and methodology of a randomized controlled trial in military veterans. Contemp Clin Trials. 2018;73:8-15. [Crossref] [PubMed] [PMC]
- Petrakis IL, Ralevski E, Desai N, Trevisan L, Gueorguieva R, Rounsaville B, et al. Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence. Neuropsychopharmacology. 2012;37(4):996-1004. [Crossref] [PubMed] [PMC]
- Na PJ, Ralevski E, Jegede O, Wolfgang A, Petrakis IL. Depression and/or PTSD comorbidity affects response to antidepressants in those with alcohol use disorder. Frontiers in psychiatry. 2022;12:768318. [Crossref] [PubMed] [PMC]
- Hruska B, Cullen PK, Delahanty DL. Pharmacological modulation of acute trauma memories to prevent PTSD: considerations from a developmental perspective. Neurobiol Learn Mem. 2014;112:122-9. [Crossref] [PubMed] [PMC]
- Hoge EA, Worthington JJ, Nagurney JT, Chang Y, Kay EB, Feterowski CM, et al. Effect of acute posttrauma propranolol on PTSD outcome and physiological responses during script-driven imagery. CNS neuroscience & therapeutics. 2012;18(1):21-7. [Crossref] [PubMed] [PMC]
- Argolo FC, Cavalcanti-Ribeiro P, Netto LR, Quarantini LC. Prevention of posttraumatic stress disorder with propranolol: A meta-analytic review. Journal of psychosomatic research. 2015;79(2):89-93. [Crossref] [PubMed]
- Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Ralevski E, et al. Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder. Biological Psychiatry. 2006;60(7):777-83. [Crossref] [PubMed]
- Krampe H, Ehrenreich H. Supervised disulfiram as adjunct to psychotherapy in alcoholism treatment. Curr Pharm Des. 2010;16(19):2076-90. [Crossref] [PubMed]
- Mann K, Torup L, Sørensen P, Gual A, Swift R, Walker B, et al. Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy. European Neuropsychopharmacology. 2016;26(12):1941-9. [Crossref] [PubMed]
- Alderman CP, McCarthy LC, Condon JT, Marwood AC, Fuller JR. Topiramate in combat-related posttraumatic stress disorder. Annals of Pharmacotherapy. 2009;43(4):635-41. [Crossref] [PubMed]
- Batki SL, Pennington DL, Lasher B, Neylan TC, Metzler T, Waldrop A, et al. Topiramate treatment of alcohol use disorder in veterans with posttraumatic stress disorder: a randomized controlled pilot trial. Alcoholism: Clinical and Experimental Research. 2014;38(8):2169-77. [Crossref] [PubMed] [PMC]
- Hamner MB, Brodrick PS, Labbate LA. Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy. Annals of Clinical Psychiatry. 2001;13:141-6. [Crossref] [PubMed]
- Baniasadi M, Hosseini G, Bordbar MRF, Ardani AR, Toroghi HM. Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial. Journal of Psychiatric Practice®. 2014;20(6):419-27. [Crossref] [PubMed]
- Nacasch N, Avni C, Toren P. Medical cannabis for treatment-resistant combat PTSD. Front Psychiatry. 2023;13:1014630. [Crossref] [PubMed] [PMC]
- Jetly R, Heber A, Fraser G, Boisvert D. The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study. Psychoneuroendocrinology. 2015;51:585-8. [Crossref] [PubMed]
- Excellence N. Post-traumatic stress disorder: NICE guideline. 2018.
- Katzman MA, Bleau P, Blier P, Chokka P, Kjernisted K, Van Ameringen M, Canadian Anxiety Guidelines Initiative Group on behalf of the Anxiety Disorders Association of Canada/Association Canadienne des troubles anxieux and McGill University. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC psychiatry. 2014;14:1-83. [Crossref] [PubMed] [PMC]
- Flanagan JC, Jones JL, Jarnecke AM, Back SE. Behavioral Treatments for Alcohol Use Disorder and Post-Traumatic Stress Disorder. Alcohol Res. 2018;39(2):181-192. [PubMed] [PMC]
- Magill M, Ray L, Kiluk B, Hoadley A, Bernstein M, Tonigan JS, Carroll K. A meta-analysis of cognitive-behavioral therapy for alcohol or other drug use disorders: Treatment efficacy by contrast condition. Journal of consulting and clinical psychology. 2019;87(12):1093. [Crossref] [PubMed] [PMC]
- Sherman AD, Balthazar M, Zhang W, Febres-Cordero S, Clark KD, Klepper M, et al. Seeking safety intervention for comorbid post-traumatic stress and substance use disorder: A meta-analysis. Brain and Behavior. 2023;13(5):e2999. [Crossref] [PubMed] [PMC]
- Najavits LM, Hien D. Helping vulnerable populations: A comprehensive review of the treatment outcome literature on substance use disorder and PTSD. Journal of clinical psychology. 2013;69(5):433-79. [Crossref] [PubMed]
- Back SE, Foa EB, Killeen TK, Mills KL, Teesson M, Cotton BD, et al. Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE): Therapist Guide. Oxford University Press.2014. [Crossref]
- Norman SB, Trim R, Haller M, Davis BC, Myers US, Colvonen PJ, et al. Efficacy of Integrated Exposure Therapy vs Integrated Coping Skills Therapy for Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2019;76(8):791-799. [Crossref] [PubMed] [PMC]